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lmu_muenchen
Prof. Dr. Andreas Dendorfer
The Myocardial ischemia has a complex pathophysiology that is not satisfactorily exploited for therapy. Our group strives to enhance the tolerance against ischemia, to protect the myocardium during reperfusion, and to regenerate muscle tissue after infarction. In the past, we have demonstrated the feasibility of preconditioning with peptide hormones, protein kinase activation, and ion channel blockade during reperfusion in experimental infarction. Molecular and translational development of these approaches will now be pursued in a new model of organotypic myocardial culture that can be applied to rodent and human tissues. Using techniques of functional imaging, genetic modification, and electrophysiology, we will address the impact of mechanotransduction, membrane integrity, and intercellular communication in ischemia and reperfusion. Long-term manipulation of 3-dimensional cultures will also enable us to study the mechanisms of stem cell integration into intact myocardial tissue, and to optimize the differentiation of stem cell-derived engineered tissue.

Contact: Andreas.Dendorfer@med.uni-muenchen.de

Members of the Dendorfer Team: 

Fischer Carola, Medical Student

Lab Technicians:
Lorenz Bärbel
Wu Mei-Ping


Recent publications:

Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, Hulot JS, Foinquinos A, Thum T, Müller CE, Dendorfer A, Laggerbauer B, Engelhardt S. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014 Dec;124(12):5385-97.

Schlipp A, Schinner C, Spindler V, Vielmuth F, Gehmlich K, Syrris P, Mckenna WJ, Dendorfer A, Hartlieb E, Waschke J. Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function. Cardiovasc Res. 2014 Nov 1;104(2):245-57.

Jung J, Husse B, Rimmbach C, Krebs S, Stieber J, Steinhoff G, Dendorfer A, Franz WM, David R. Programming and isolation of highly pure physiologically and pharmacologically functional sinus-nodal bodies from pluripotent stem cells. Stem Cell Reports. 2014 April 17; 2(5):592-605.

Su YX, Benedek GA, Sieg P, Liao GQ, Dendorfer A, Meller B, Rades D, Klinger M, Hakim SG. Radioprotective effect of lidocaine on neurotransmitter agonist-induced secretion in irradiated salivary glands. PLoS One 2013; 8(3):e60256.

Ashoff A, Qadri F, Eggers R, Jöhren O, Raasch W, Dendorfer A. Pioglitazone prevents capillary rarefaction in streptozotocin-diabetic rats independently of glucose control and vascular endothelial growth factor expression. J. Vasc. Res. 2012; 49(3):260-6.

Hakim SG, Benedek GA, Su YX, Jacobsen HC, Klinger M, Dendorfer A, Hemmelmann C, Meller B, Nadrowitz R, Rades D, Sieg P. Radioprotective effect of lidocaine on function and ultrastructure of salivary glands receiving fractionated radiation. Int. J. Radiat. Oncol. Biol. Phys. 2012 March 15; 82(4):e623-30.

Lohmann K, Uflacker N, Erogullari A, Lohnau T, Winkler S, Dendorfer A, Schneider SA, Osmanovic A, Svetel M, Ferbert A, Zittel S, Kuhn AA, Schmidt A, Altenmuller E, Munchau A, Kamm C, Wittstock M, Kupsch A, Moro E, Volkmann J, Kostic V, Kaiser FJ, Klein C, Bruggemann N. Identification and functional analysis of novel THAP1 mutations. Eur J Hum Genet 2012 Februar: 20(2):171-5.

Brandenburger M, Wenzel J, Bogdan R, Richardt D, Nguemo F, Reppel M, Hescheler J, Terlau H, Dendorfer A. Organotypic slice culture from human adult ventricular myocardium. Cardiovasc Res. 2012 Jan 1; 93(1):50-9.

Belge G, Radtke A, Meyer A, Stegen I, Richardt D, Nimzyk R, Nigam V, Dendorfer A, Sievers HH, Tiemann M, Buchwalow I, Bullerdiek J, Mohamed SA. Upregulation of the high mobility group AT-hook 2 gene in acute aortic dissection is potentially associated with endothelial-mesenchymal transition. Histol Histopathol 2011 August; 26(8):1029-37.

Osmanovic A, Dendorfer A, Erogullari A, Uflacker N, Braunholz D, Rakovic A, Vierke G, Gil-Rodriguez C, Munchau A, Albrecht M, Bruggemann N, Gillessen-Kaesbach G, Klein C, Lohmann K, Kaiser FJ. Truncating mutations in THAP1 define the nuclear localization signal. Mov Disord 2011 July; 26(8):1565-7.

Chen P, Dendorfer A, Finol-Urdaneta RK, Terlau H, Olivera BM. Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem 2010 May 14; 285(20):14882-9.

Wenzel J, Grabinski N, Knopp CA, Dendorfer A, Ramanjaneya M, Randeva HS, Ehrhart-Bornstein M, Dominiak P, Johren O. Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells. Am J Physiol Regul Integr Comp Physiol 2009 November; 297(5):R1601-R1609.

Ramot Y, Gaspar E, Dendorfer A, Langbein L, Paus R. The 'melanocyte-keratin' mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6 in situ. Br J Dermatol 2009 October; 161(4):933-8.

Koch M, Bonaventura K, Spillmann F, Dendorfer A, Schultheiss HP, Tschope C. Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model. Biol Chem 2008 June; 389(6):719-23.

Jacobsen HC, Hakim SG, Lauer I, Dendorfer A, Wedel T, Sieg P. Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca. J Craniomaxillofac Surg 2008 June; 36(4):227-33.

Heidbreder M, Naumann A, Tempel K, Dominiak P, Dendorfer A. Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways. Cardiovasc Res 2008 April 1; 78(1):108-15.

Johren O, Dendorfer A, Dominiak P, Raasch W. Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats. Brain Res 2007 December 12; 1184:160-7.

Schaefer U, Kurz T, Bonnemeier H, Dendorfer A, Hartmann F, Schunkert H, Richardt G. Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress? J Intern Med 2007 February; 261(2):188-200.

Heidbreder M, Qadri F, Johren O, Dendorfer A, Depping R, Frohlich F, Wagner KF, Dominiak P. Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin. Biochem Biophys Res Commun 2007 January 12; 352(2):437-43.

Schrader J, Kulschewski A, Dendorfer A. Inhibition of the renin-angiotensin system and the prevention of stroke. Am J Cardiovasc Drugs 2007; 7(1):25-37.