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Chairman
Principal Investigators
Staff
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lmu_muenchen
Barbara Schraml, PhD
Barbara Schraml leads an Emmy-Noether-Research-Group and is associated with the SFB914 ‘Trafficking of Immune Cells in Inflammation, Development and Disease’ (http://www.sfb914.med.uni-muenchen.de/index.html). Her research focuses on understanding the precise organ-specific functions of dendritic cells in immunity. Dendritic cells, along with monocytes and macrophages, comprise a family of cells called mononuclear phagocytes. They are versatile controllers of the immune system with crucial roles in immune regulation and tissue homeostasis. An important question is to what extent the functions of these mononuclear phagocytes are dictated by their unique ontogeny versus the environmental cues they receive from their surroundings. These questions are in part addressed using mouse models that allow for the definition and visualization of dendritic cells based on their ontogenetic descendence from committed precursors (Schraml et al., Cell 2013). The major challenges in the design of future therapies are to target specific components of the immune response in the absence of general immunosuppression. Understanding the unique functions of dendritic cells in the context of their microenvironment will help determine their potential for targeted immunotherapy.
Homepage:www.schraml-lab.de
Contact: barbara.schraml@med.uni-muenchen.de
Members of the Schraml Team: 

Postdocs:
Maria Szente-Pasztoi, Dr.rer.nat
Natallia Salei, Dr.rer.nat.

PhD-students:
Dalia Pakalniškytė
Nikolaos Papaioannou
Stephan Rambichler
Johanna Salvermoser

Lab Technician:
Claudia Schmalhofer

We are looking for excellent people, please apply with your CV and 2 references to
barbara.schraml@med.uni-muenchen.de

Recent publications:

Helft J, Böttcher J, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, Reis E Sousa C. GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells. Immunity. 2015 Jun 16;42(6):1197-211.

Poltorak MP, Schraml BU. Fate mapping of dendritic cells. Front Immunol. 2015 May 4;6:199.

Schraml BU, Reis e Sousa C. Defining Dendritic Cells. Current Opinion in Immunology . 2015 ePub Dec 2014.

van Blijswijk J, Schraml BU, Rogers NC, Whitney PG, Zelenay S, Acton SE, Reis E Sousa C. Altered Lymph Node Composition in Diphtheria Toxin Receptor-Based Mouse Models To Ablate Dendritic Cells. J Immunol, 19. pii: 1401999. 2014 [Epub ahead of print].

Whitney PG, Bär E, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis E Sousa C. Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog. 2014 Jul 17;10(7):e1004276.

Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, Segura E, Tussiwand R, and Yona S. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat.Rev.Imm. 2014 Aug;14(8):571-8.

Schraml BU, van Blijswijk J, Zelenay S, Whitney PG, Filby A, Acton SE, Rogers NC, Moncaut N, Carvajal JJ, Reis e Sousa C. Genetic tracing via expression history of DNGR-1 defines dendritic cells as a hematopoietic lineage. Cell, 2013 154(4):843-858.

van Blijswijk J, Schraml BU, Reis e Sousa C. Advantages and limitations of mouse models to deplete dendritic cells. Eur. J Immunology. 2013 Jan;43(1):22-6.

Zelenay S, Keller AM, Whitney PG, Schraml BU, Deddouche S, Rogers NC, Schulz O, Sancho D, Reis e Sousa C. The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest. 2012 1;122(5):1615-27.

Poulin LF, Reyal Y, Uronen-Hansson H, Schraml BU, Sancho D, Murphy KM, Håkansson UK, Moita LF, Agace WW, Bonnet D, Reis e Sousa C. DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood; 2012 Jun 21;119(25):6052-62.

Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B and T cells. Nat Immunol. 2011 Jun;12(6):536-43.

Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM. Batf expands AP-1 target specificity to control TH17 differentiation. Nature. 2009 Jul 16;460(7253):405-9.

Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. BATF3 deficiency reveals a critical role for CD8+ dendritic cells in cytotoxic T cell immunity. Science. 2008 Nov 14;322(5904):1097-100.

Liszewski MK, Leung MK, Schraml B, Goodship TH, Atkinson JP. Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol. Immunol. 2007 Mar;44(7):1559-68.

Schraml B, Baker MA, Reilly BD. A complement receptor for opsonized immune complexes on erythrocytes from Oncorhynchus mykiss but not Ictalarus punctatus. Mol. Immunol. 2006 Apr; 43(10): 1595-603. .