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Chairman
Principal Investigators
Staff
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lmu_muenchen
Christoph Scheiermann, PhD
Dr. Christoph Scheiermann has been awarded the prestigious Emmy-Noether-Grant from the Deutsche Forschungsgemeinschaft. His group focuses on circadian rhythms in the immune response and is associated with the SFB914 ‘Trafficking of Immune Cells in Inflammation, Development and Disease’ (http://www.sfb914.med.uni-muenchen.de/index.html). The recruitment of leukocytes to tissues and their localization within tissues plays a crucial role in the immune response. Recruitment of leukocytes to tissues underlies a circadian, i.e daily rhythm. This supports accumulating evidence for circadian oscillations in many components of the immune system with the potential to affect disease onset and therapies. The group studies leukocyte migration patterns using various intravital microscopy techniques in different tissues. Specifically, the focus is on how neural influences regulate the circadian migration of leukocytes to tissues, which promigratory factors control these rhythms and whether they can be altered by surgical, pharmacological or genetic interventions. The goal is to provide novel mechanistic insight into the systemic regulation of leukocyte trafficking with the potential for time-based, i.e. chronotherapeutic, interventions in inflammatory diseases.
Contact: christoph.scheiermann@med.uni-muenchen.de
Members of the Scheiermann Team: 

PhD-students:
David Druzd
Alba de Juan

Lab Technicians:
Kerstin Kraus

We are looking for excellent people, please apply with your CV and 2 references to
christoph.scheiermann@med.uni-muenchen.de

Recent publications:

Druzd D, de Juan A, Scheiermann C. Circadian rhythms in leukocyte trafficking. Semin Immunopathol. 2014 March; 36:149-62.

Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013. 502:637-43.

Druzd D, Scheiermann C. Some monocytes got rhythm. Science. 2013. 341:1462-4.

Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L., und Frenette, P. S. Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat. Med. 2013 [Epub ahead of print]

Scheiermann C, Kunisaki Y, Frenette PS. Circadian control of the immune system. Nat. Rev. Immunol. 2013 13:190-8.

Frenette, P. S., Pinho, S., Lucas, D., und Scheiermann, C. Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine. Annu. Rev. Immunol. 2013 31:285-316.

Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A., Jang, J. E., Zhang, D., Hashimoto, D., Merad, M., and Frenette, P. S. Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity. 2012 37:290-301.

Almeida, C. B., Scheiermann, C., Jang, J. E., Prophete, C., Costa, F. F., Conran, N., and Frenette, P. S. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Blood. 2012 120:2879-88.

Chow, A., Lucas, D., Hidalgo, A., Méndez-Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., Tanako, M., Merad, M., and Frenette, P. S. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 2011 208:261-71.

Scheiermann, C., Kunisaki, Y., Jang, J., and Frenette, P. S. Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr. Opin. Hematol. 2010 17:25-30.

Scheiermann, C., Colom, B., Meda, P., Patel, N. S., Voisin, M. B., Marrelli, A., Woodfin, A., Pitzalis, C., Thiemermann, C., Aurrand-Lions, M., Imhof, B. A., and Nourshargh, S. Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler. Thromb. Vasc. Biol. 2009 29:1509-15.

Scheiermann, C., Meda, P., Aurrand-Lions, M., Madani, R., Yiangou, Y., Coffey, P., Salt, T. E, Ducrest-Gay, D., Caille, D., Howell, O., Reynolds, R., Lobrinus, A., Yu, A. S., Adams, R. H., Anand, P., Imhof, B. A., and Nourshargh, S. Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science 2007 318:1472-1475.

Bradfield, P. F., Scheiermann, C., Nourshargh, S., Ody, C., Luscinskas, F. W., Rainger, G. E., Nash, G. B., Miljkovic-Licina, M., Aurrand-Lions, M., and Imhof, B. A. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood 2007 110:2545-2555.

Woodfin, A., Reichel, C. A., Khandoga, A., Corada, M., Voisin, M. B., Scheiermann, C., Haskard, D. O., Dejana, E., Krombach, F., and Nourshargh, S. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood 2007 110:1848-56.