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PD Dr.med.vet. Heike Beck
The Beck lab is working on the role of cellular redox-systems on tumor growth and tumor angiogenesis. To study the specific functions of involved enzymes, several mouse lines with specific mutations in the glutathion- and thioredoxin-dependent systems are used. An additional focus of our lab is post-ischemic repair mechanisms following stroke. In this context several transcription factors are investigated concerning their role in gliosis, inflammation and post-ischemic angiogenesis.

Contact: Heike.Beck@med.uni-muenchen.de
Members of the Beck Team: 

Nuernbergk Christoph, MD student

Lab Technicians:
Gössel Dorothee
Kiesl Dora
Semisch Matthias

Recent publications:

Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol, 2016 May;131(5):753-73.

Kameritsch P, Kiemer F, Beck H, Pohl U, Pogoda K. Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1. Biochim Biophys Acta, 2015 Nov;1853 (11 Pt A):2907-17.

Hellfritsch J, Kirsch J, Schneider M, Perisic T, Wortmann M, Frijhoff J, Dagnell M, Fey T, Esposito I, Kölle P, Pogoda K, Friedmann Angeli JO, Ingold I, Kuhlencordt P, Östman A, Pohl U, Conrad C, Beck H. Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis. Antioxidants & Redox Signaling, Antioxid Redox Signal, 2015 Apr 10;22(11):938-950.

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.

Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, Vegi N, Kölle P, Kuhlencordt P, Walch A, Bornkamm GW, Pohl U, Conrad M, Beck H. Combined Deficiency in Glutathione Peroxidase 4 (Gpx4) and Vitamin E Causes Multi-Organ Thrombus Formation and Early Death in Mice. Circulation Research, 2013 Aug 2;113(4):408-17.

Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos AK, Rao GN, Thomas EA, Wang R, Ehrlich M: Egr-1 induces DARPP-32 expression in striatal medium spiny. neurons via conserved intragenic element. J Neuroscience, 2012 May 16;32(20):6808-18.

Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H, De BD, Vermoesen K, Bannai S, Smolders I, Conrad M, Plesnila N, Sato H, Michotte Y. Dopaminergic neurons of system x(c)-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB J 2011 April;25(4):1359-69.

Beck H, Raab S, Copanaki E, Heil M, Scholz A, Shibuya M, Deller T, Machein M, Plate KH. VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke model. J Neuropathol Exp Neurol 2010 February;69(2):168-75.

Mandal PK, Schneider M, Kolle P, Kuhlencordt P, Forster H, Beck H, Bornkamm GW, Conrad M. Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation. Cancer Res 2010 November 15;70(22):9505-14.

Schneider M, Wortmann M, Mandal PK, Arpornchayanon W, Jannasch K, Alves F, Strieth S, Conrad M, Beck H. Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia 2010 March;12(3):254-63.

Trabold R, Eros C, Zweckberger K, Relton J, Beck H, Nussberger J, Muller-Esterl W, Bader M, Whalley E, Plesnila N. The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice. J Cereb Blood Flow Metab 2010 January;30(1):130-9.

Beck H, Plate KH: Angiogenesis after Cerebral Ischemia Acta Neuropathol. 2009 May;117(5):481-96, Review

Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK. Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol 2008 July;173(1):77-92.

Soerensen J, Jakupoglu C, Beck H, Forster H, Schmidt J, Schmahl W, Schweizer U, Conrad M, Brielmeier M. The role of thioredoxin reductases in brain development. PLoS ONE 2008;3(3):e1813.

Comati A, Beck H, Halliday W, Snipes GJ, Plate KH, Acker T. Upregulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha in leptomeningeal vascular malformations of Sturge-Weber syndrome. J Neuropathol Exp Neurol 2007 January;66(1):86-97.