Institut Studium Forschung Leistungen Publikationen Kontakt

Chairman
Principal Investigators
Staff
Career Opportunities
 
lmu_muenchen
Prof. Dr. rer. nat Jörg Renkawitz

Immune cells represent a fascinating model to understand the underlying principles of cell motility (cell migration, macropinocytosis, leukocyte trafficking), as innate and adaptive immune responses critically dependent on the highly efficient capability to engulf extracellular material and to migrate through various extracellular micro-environments. Dr. Jörg Renkawitz has been awarded the endowed Peter Hans Hofschneider Professor for Molecular Medicine. His group employs immune cells such as dendritic cells, macrophages and neutrophils to decipher the molecular and and cell biological principles of cell motility in homeostasis and inflammation. The Renkawitz Lab interdisciplinary combines advanced live-cell microscopy, genetic-engineering (e.g. CRISPR), custom-made micro-environments (e.g. microfluidics, 3D collagen matrices) and unbiased system-wide approaches. The group is located in the modern building of the Biomedical Center Munich (BMC) of the LMU Munich, associated to the SFB914 “Trafficking of Immune Cells in Inflammation, Development and Disease” and its graduate program (http://www.sfb914.med.uni-muenchen.de/index.html).

Open Positions (see ‘Members of the Renkawitz Team’ for details):
We are looking for an excellent PhD student!
We are looking for excellent Master students!

Contact: Joerg.Renkawitz@med.uni-muenchen.de
Twitter: @renkawitzteam
Members of the Renkawitz Team: 

Petra Kameritsch, Dr.
Kasia Stefanowski

We are a young, dynamic and growing team, looking for excellent new team members. Ph.D./Dr. students, master students and postdocs with an interest in the cell biological principles of cell motility (cell migration, macropinocytosis, leukocyte trafficking) and a background in cell biology, molecular biology, imaging, immunology, or bioengineering are encored to apply. If interested, please send your application including your covering letter, CV, and two reference contacts in one PDF to Joerg.Renkawitz@med.uni-muenchen.de.

Recent publications:

Renkawitz J, Reversat A, Leithner A, Merrin J, Sixt M. (2018) Micro-engineered ‘Pillar Forests’ to Study Cell Migration in Complex but Controlled 3D Environments. Methods in Cell Biology, 147:79-91

Hons M, Kopf A, Hauschild R, Leithner A, Gaertner F, Abe J, Renkawitz J, Stein JV, Sixt M. (2018) Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Nat Immunol. 19:606-16.

Leithner A, Renkawitz J, De Vries I, Hauschild R, Häcker H, Sixt M. (2018) Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration. Eur J Immunol. 48:1074-77.

Frick C, Dettinger P, Renkawitz J, Jauch A, Berger CT, Recher M, Schroeder T, Mehling M. (2018) Nano-scale microfluidics to study 3D chemotaxis at the single cell level. PLoS One. 13:e0198330.

Lademann CA, Renkawitz J, Pfander B, Jentsch S. (2017) INO80-C removes H2A.Z to promote presynaptic filament formation during homologous recombination. Cell Reports. 9:1294-1303.

Renkawitz J, Sixt M. (2016) A Radical Break: Restraining Neutrophil Migration. Developmental Cell. 38:448-50 (Preview). Renkawitz J, Sixt M. (2016) Formin’ a nuclear protection. Cell. 167:1448-1449 (Preview).

Renkawitz J*, Lademann CA*, Jentsch S. (2014) Mechanisms and principles of homology search during recombination. Nat Rev Mol Cell Biol. 15:369-83 (Review) (*contributed equally).

Renkawitz J, Lademann CA, Jentsch S. (2013) ?H2AX spreading linked to homology search. Cell Cycle. 12:2526-7 (Preview).

Renkawitz J, Lademann CA, Kalocsay M, Jentsch S. (2013) Monitoring homology search during DNA double-strand break repair in vivo. Molecular Cell. 50:261-72

Renkawitz J, Sixt M. (2010) Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep. 11:744-50. (Review)

Renkawitz J, Schumann K, Weber M, Lämmermann T, Pflicke H, Piel M, Polleux J, Spatz JP, Sixt M. (2009) Adaptive force transmission in amoeboid cell migration. Nat Cell Biol. 11:1438-43.

Lämmermann T, Renkawitz J, Wu X, Hirsch K, Brakebusch C, Sixt M. (2009) Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood. 113:5703-10.

Mertins P, Eberl HC, Renkawitz J, Olsen JV, Tremblay ML, Mann M, Ullrich A, Daub H. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics. 7:1763-77.

Geiger SR, Kuhn CD, Leidig C, Renkawitz J, Cramer P. (2008) Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64:413-8.