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PD Dr.rer.nat. Markus Rehberg

The rapidly developing field of nanomedicine aims to apply nanotechnology to medicine. Due to numerous unique physicochemical features, a high potential for the clinical utilization of nanomaterials is predicted. Of particular interest is the development of nanoagent-based innovative therapeutic strategies for the prevention and treatment of inflammatory diseases. By using advanced in vivo microscopy techniques, our group investigates, the spatio-temporal dynamics of the distribution as well as the cellular interactions of different novel nanoconstructs at the microscopic tissue/cell level in vivo. Moreover, we aim to target switchable nanoconstructs to distinct immune cell populations, in order to selectively alter specific cellular functions.


Contact: Markus.Rehberg@lrz.uni-muenchen.de
Members of the Rehberg Team:

Gayer Jan (FöFoLe)
Nekolla Katharina, M.Sc. (DFG SFB 1032)
Sellner Sabine (DFG SFB 1032)

Lab Technician:
Fahney Claudia

Recent publications:

Dietzel S, Pircher J, Nekolla AK, Gull M, Brändli AW, Pohl U, Rehberg M. Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy. PLoS One. 2014 Jun 16;9(6):e99615. doi: 10.1371/journal.pone.0099615 2.

Uhl B, Zuchtriegel G, Puhr-Westerheide D, Praetner M, Rehberg M, Fabritius M, Hessenauer M, Holzer M, Khandoga A, Fürst R, Zahler S, Krombach F, Reichel CA. (2014) Tissue-type plasminogen activator promotes postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties. Arterioscler Thromb Vasc Biol. 2014; Apr 24. [Epub ahead of print]

Lerchenberger M, Uhl B, Stark K, Zuchtriegel G, Eckart A, Miller M, Puhr-Westerheide D, Praetner M, Rehberg M, Khandoga AG, Lauber K, Massberg S, Krombach F, Reichel CA. (2013) Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue. Blood1;122(5):770-80.

Collmann E, Bohnacker T, Marone R, Dawson J, Rehberg M, Stringer R, Krombach F, Burkhart C, Hirsch E, Hollingworth GJ, Thomas M, Wymann MP. (2013) Transient targeting of PI3K acts as roadblock in mast cells’ route to allergy. J Allergy Clin Immunol. 14. doi:pii: S0091-6749(13)00428-4.

Samtleben S, Jaepel J, Fecher C, Andreska T,  Rehberg M, Blum R (2013) Direct imaging of ER calcium with targetedeEsterase induced dye loading (TED). J Vis Exp. 7(75): doi: 10.3791/50317

Fraccaroli A, Franco C, Rognoni E, Neto F,  Rehberg M, Aszodi A, Wedlich-Söldner R, Pohl U, Gerhardt H, Montanez E. (2012) Visualization of endothelial actin cytoskeleton in the mouse retina. PLoS One 7(10):e47488

Rehberg M, Leite CF, Mildner K, Horstkotte J, Zeuschner D, Krombach F. (2012) Surface chemistry of quantum dots determines their behavior in postischemic tissue. ACS Nano 6(2): 1370-1379.

Rehberg M, Krombach F, Pohl U, Dietzel S. (2011) Label-free 3D visualization of cellular and tissue structures in intact muscle with second and third harmonic generation microscopy. PLoS One 6: e28237.

Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM, Fürst R. (2011) Inhibitor of apoptosis proteins as novel targets in inflammatory processes.Arterioscler Thromb Vasc Biol. 31(10): 2240-2250.

Reichel CA, Uhl B, Lerchenberger M, Puhr-Westerheide D, Rehberg M, Liebl J, Khandoga A, Schmalix W, Zahler S, Deindl E, Lorenzl S, Declerck PJ, Kanse S, Krombach F. (2011) Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of uPAR. Circulation 124: 1848-1859.

Reichel CA, Lerchenberger M, Uhl B, Rehberg M, Berberich N, Zahler S, Wymann MP, Krombach F. (2011) Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. PlosOne6(2): e17229.

Rehberg M, Praetner M, Leite CF, Bihari P, Reichel CA, Mildner K, Duhr S, Zeuschner D, Krombach F. (2010) Quantum dots modulate leukocyte adhesion and transmigration depending on their surface modification. Nano Letters 10: 3656‐3664.

Praetner M, Rehberg M, Bihari P, Lerchenberger M, Uhl B, Holzer M, Eichhorn ME, Fürst R, Perisic T, Reichel CA, Welsch U, Krombach F. (2010) The contribution of the capillary endothelium to blood clearance and tissue deposition of anionic quantum dots in vivo. Biomaterials 31: 6692‐6700.

Rehberg M, Krombach F, Pohl U, Dietzel S. (2010) Signal improvement in multi-photon microscopy by reflection with simple mirrors near the sample. J Biomed Opt15: 026017.

Bihari P, Holzer M, Praetner M, Fent J, Lerchenberger M, Reichel C, Rehberg M, Lakatos S, Krombach F. (2010) Single-walled carbon nanotubes activate platelets and accelerate thrombus formation in the microcirculation.Toxicology 269: 148‐154.

Reichel CA, Rehberg M, Lerchenberger M, Berberich N, Bihari P, Khandoga AG, Zahler S, Krombach F. (2009) Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators. Arterioscler Thromb Vasc Biol. 29(11): 1787-1793.

Khandoga AG, Khandoga A, Reichel CA, Bihari P, Rehberg M, Krombach F. (2009) In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue. PloS One 4(3): e4693.

Cera MR, Fabbri M, Molendini C, Corada M, Orsenigo F, Rehberg M, Reichel CA, Krombach F, Pardi R, Dejana E. (2009) JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. J Cell Sci.122: 268-277.

Bihari P, Vippola M, Schultes S, Praetner M, Khandoga AG, Reichel CA, Coester C, Tuomi T, Rehberg M, Krombach F. (2008) Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol. 6(5):14.

Fürst R, Bubik M, Bihari P, Mayer BA, Khandoga AG, Hoffmann F, Rehberg M, Krombach F, Zahler S, Vollmar AM. (2008) Atrial natriuretic peptide protects against histamine-induced endothelial barrier dysfunction in vivo. Mol Pharmacol. 74(1): 1-8.

Reichel CA, Rehberg M, Bihari P, Moser C, Linder S, Khandoga A, Krombach F. (2008) Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling. J Leukoc Biol. 83(4): 864-874.

Rehberg M, Lepier A, Solchenberger B, Osten P, Blum R. (2008) A new non-disruptive strategy to target calcium indicator dyes to the endoplasmatic reticulum. Cell Calcium 44(4): 386-399.