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lmu_muenchen
Prof. Dr.med. Ulrich Pohl
The Pohl lab investigates cellular mechanisms controlling local blood flow in tissues.  Current work focuses on signalling processes within the endothelium and microvascular smooth muscle. There are three main projects: i) the functional role of connexins and gap junctions in the vascular wall, especially in the coordination of cell responses to vasocactive stimuli, the control cell migration and functional maturation of cells, ii) the significance of cell-matrix-interactions for the endothelial and smooth muscle response to mechanical stimuli and iii) the control of smooth muscle tone by changes of calcium sensitivity of the contractile apparatus. Studies are performed in cultured cells as well as isolated, long term perfused resistance arteries showing loss or gain of function after transfection. These functional studies on isolated vessels are complemented by intravital microscopy studies, mainly in skeletal muscle preparations. In collaboration with the clinical guest group of Florian Kroetz, we are also studying the role of endothelial factors, especially EDHF on blood platelets in vivo.

Contact: upohl@lmu.de
Members of the Pohl Team: 

Blodow Stephanie, Dr. med. vet.
Kameritsch Petra, Dr. rer. nat. (Ph.D.)
Kirsch Julian, Dr. biol. hum.
Pogoda Kristin, Dr. rer. nat. (Ph.D.)
Schubert Michael, PhD Student
Schneider Holger, Dr. med.

Lab Technicians:
Bscheider Britta
Stefanowski Katarzyna
Wilhelm-Forster Ulrike

Recent publications:

Schneider H, Schubert KM, Blodow S, Kreutz CP, Erdogmus S, Wiedenmann M, Qiu J, Fey T, Ruth P, Lubomirov LT, Pfitzer G, Mederos Y, Schnitzler M, Hardie DG, Gudermann T, Pohl U. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension 2015 Jun 1. [Epub ahead of print]

Dietzel S, Pircher J, Nekolla AK, Gull M, Brändli AW, Pohl U, Rehberg M. Label-free determination of hemodynamic parameters in the microcirculation with third harmonic generation microscopy. PLoS One 2014 Jun 16; 9(6):e99615.

Köppl T, Schneider M, Pohl U, Wohlmuth B. The influence of an unilateral carotid artery stenosis on brain oxygenation. Med Eng Phys. 2014 Jul; 36(7):905-14.

Pogoda K, Füller M, Pohl U, Kameritsch P. NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions. Cell Commun Signal. 2014 May 15; 12:33.

Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, Vegi N, Kölle P, Kuhlencordt P, Walch A, Bornkamm GW, Pohl U, Conrad M, Beck H (2013) Combined Deficiency in Glutathione Peroxidase 4 (Gpx4) and Vitamin E Causes Multi-Organ Thrombus Formation and Early Death in Mice. Circulation Research 2013 Aug 2; 113(4):408-17.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fassler R, Deutsch U, Kupatt C. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest 2013 Jul 1; 123:3436–3445.

Kameritsch P, Khandoga N, Pohl U, Pogoda K. Gap junctional communication promotes apoptosis in a connexin-type-dependent manner. Cell Death Dis. 2013 Apr 11; 4:e584.

Kameritsch P, Pogoda K, Ritter A, Münzing S, Pohl U. Gap junctional communication controls the overall endothelial calcium response to vasoactive agonists. Cardiovasc Res. 2012 Mar 1;93(3):508-15.

Kameritsch P, Pogoda K, Pohl U. Channel-independent influence of connexin 43 on cell migration. Biochim Biophys Acta. 2012 Aug;1818(8):1993-2001.

Mogensen C, Bergner B, Wallner S, Ritter A, d'Avis S, Ninichuk V, Kameritsch P, Gloe T, Nagel W, Pohl U. Isolation and functional characterization of pericytes derived from hamster skeletal muscle. Acta Physiol (Oxf). 2011 Apr;201(4):413-26

Hennig T, Mogensen C, Kirsch J, Pohl U, Gloe T. Shear stress induces the release of an endothelial elastase: role in integrin α(v)β(3)-mediated FGF-2 release. J Vasc Res. 2011;48(6):453-64

Behrens J, Kameritsch P, Wallner S, Pohl U, Pogoda K. The carboxyl tail of Cx43 augments p38 mediated cell migration in a gap junction independent manner. Eur J Cell Biol, 2010 August 18;89:828-38.

Sarelius I, Pohl U. Control of muscle blood flow during exercise: local factors and integrative mechanisms.
Acta Physiol (Oxf) 2010 March 26.

Rehberg M, Krombach F, Pohl U, Dietzel S. Signal improvement in multiphoton microscopy by reflection with simple mirrors near the sample. J Biomed Opt 2010 March;15(2):026017.

Krötz F, Hellwig N, Burkle MA, Lehrer S, Riexinger T, Mannell H, Sohn HY, Klauss V, Pohl U. A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo. Cardiovasc Res 2010 February 1;85(3):542-50.

Mannell H, Hammitzsch A, Mettler R, Pohl U, Krötz F. Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt. Cell Signal 2010 January;22(1):88-96.

Struthmann L, Hellwig N, Pircher J, Sohn HY, Buerkle MA, Klauss V, Mannell H, Pohl U, Krötz F. Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosis in vivo. J Thromb Haemost 2009 October;7(10):1727-35.

Lidington D, Peter BF, Meissner A, Kroetsch J, Pitson SM, Pohl U, Bolz SS. The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries. Arterioscler Thromb Vasc Biol 2009 September 3.

Krötz F, Hellwig N, Burkle MA, Lehrer S, Riexinger T, Mannell H, Sohn HY, Klauss V, Pohl U. A sulfaphenazole-sensitive EDHF opposes platelet endothelium interactions in vitro and in the hamster microcirculation in vivo. Cardiovasc Res 2009 August 28.

Pohl U. New tools for physiology. Physiology (Bethesda ) 2008 October;23:234.

Peter BF, Lidington D, Harada A, Bolz HJ, Vogel L, Heximer S, Spiegel S, Pohl U, Bolz SS. Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone. Circ Res 2008 June 26.

Pohl U. How to measure science in physiology. Physiology (Bethesda ) 2008 February;23:2.

Mannell H, Hellwig N, Gloe T, Plank C, Sohn HY, Groesser L, Walzog B, Pohl U, Krötz F. Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. J Vasc Res 2008 February;45(2):153-63.

Rodenwaldt B, Pohl U, de WC. Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculation. Am J Physiol Heart Circ Physiol 2007 May;292(5):H2341-H2348.

Krötz F, Keller M, Derflinger S, Schmid H, Gloe T, Bassermann F, Duyster J, Cohen CD, Schuhmann C, Klauss V, Pohl U, Stempfle HU, Sohn HY. Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. Hypertension 2007 January;49(1):201-8.