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Principal Investigators
Career Opportunities
Prof. Dr.rer.nat. Elisabeth Deindl
The development and remodeling of vessels is a crucial process in many physiological and pathophysiological processes making it topic of in-depth research in laboratories all around the world. Vascular occlusive diseases are head of death causing aliments in industrialized countries. Growth of collateral arteries (arteriogenesis) bypassing a site of stenosis is the most relevant naturally occurring adaptive process protecting tissue from ischemic injury and death. The main research interest of the group around E. Deindl is the identification of the molecular pathways of arteriogenesis from increased mechanical load – the trigger of collateral growth - to cell proliferation. In detail, we are studying how physical forces are translated into biological signals, how these signals are propagated within a cell, finally resulting in cell proliferation, as well as how signals are transmitted from cell to cell (i.e. from endothelial cells to smooth muscle cells).


Therapeutic Neovascularization – Quo Vadis?
Arteriogenesis - Molecular Regulation, Pathophysiology and Therapeutics I
Arteriogenesis - Molecular Regulation, Pathophysiology and Therapeutics II
Arteriogenesis and Therapeutic Neovascularization
Arteriogenesis and Therapeutic Angiogenesis (in progress)
Members of the Deindl Team: 

Konda Kumaraswami, biochemist
Dr. Lasch Manuel, MD
Simon Rutkowski, MD
Sebastian Beck, MD student
Philipp Götz, MD student
Matthias Kübler, MD student
Franziska Sciuk, MD student
Christoph Arnholdt, MD student
Lisa Bobrowski, MD student

Lab Technicians:
Eder Christine

Recent publications:

Preissner KT, Fischer S, Deindl E (2020) ) ) Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection. Front Cell Dev Biol 8:619221. doi: 10.3389/fcell.2020.619221

Lasch M, Kumaraswami K, Nasiscionyte S, Kircher S, van den Heuvel D, Meister S, Ishikawa-Ankerhold H, Deindl E (2020) ) ) RNase A Treatment Interferes with Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue. Front Physiol 11:576736. doi: 10.3389/fphys.2020.576736

Deindl E, Quax PHA (2020) Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects. Cells: 9(6) doi: 10.3390/cells9061439

Deindl E, Quax PHA (2020) From Increased Fluid Shear Stress to Natural Bypass Growth. Int J Mol Sci: 21(10) doi: 10.3390/ijms21103707

Kumaraswami K, Salei N, Beck S, Rambichler S, Kluever AK, Lasch M, Richter L, Schraml BU, Deindl E (2020) A Simple and Effective Flow Cytometry-Based Method for Identification and Quantification of Tissue Infiltrated Leukocyte Subpopulations in a Mouse Model of Peripheral Arterial Disease. Int J Mol Sci: 21(10)doi: 10.3390/ijms21103593

Lasch M, Caballero Martinez A, Kumaraswami K, Ishikawa-Ankerhold H, Meister S, Deindl E (2020) Contribution of the potassium channels KV1.3 and KCa3.1 to smooth muscle cell proliferation in growing collateral arteries. Cells:9,913 doi:10.3390/cells9040913

Kluever A-C, Braumandl A, Fischer S, Preissner KT, Deindl E (2019) The extraordinary role of extracellular RNA in arteriogenesis, the growth of collateral arteries. Int J Mol Sci:20(24) doi: 10.3390/ijms20246177

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E. (2019) Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction. Blood:134(17):1469-1479 doi: 10.1182/blood.2019001392

Wagner M, Mahlmann A, Deindl E, Zuschratter W, Riek-Burchardt M, Kostin S, Luani B, Baer C, Youssef A, Herold J. (2019) Clinical improvement and enhanced collateral vessel growth after xenogenic monocyte transplantation. Am J Transl Res:11(7):4063-4076 eCollection 2019

Thulasingam S, Krishnasamy S, Raj C D, Lasch M, Vedantham S, Deindl E.(2019) Insulin Treatment Forces Arteriogenesis in Diabetes Mellitus by Upregulation of the Early Growth Response-1 (Egr-1) Pathway in Mice. Int J Mol Sci:20(13) doi: 10.3390/ijms20133320.

Beck S, Konda K, Salei N, Rambichler S, Braumandl A, Schraml BU, Deindl E. (2019). Flow cytometric analysis of leukocytes in soft tissue. Gefässchirurgie:

Elsemüller AK, Tomalla V, Gärtner U, Troidl K, Jeratsch S, Graumann J, Baal N, Hackstein H, Lasch M, Deindl E, Preissner KT, Fischer S. (2019) Characterization of mast cell-derived rRNA-containing microvesicles and their inflammatory impact on endothelial cells. FASEB J:33(4):5457-5467 doi: 10.1096/fj.201801853RR

Lasch M, Nekolla K, Klemm AH, Buchheim JI, Pohl U, Dietzel S, Deindl E.(2019) Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning. Mol Cell Biochem: 453(1-2):41-51 doi: 10.1007/s11010-018-3430-9.

Kluever AK, Deindl E. (2018) Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, Ischemia/Reperfusion Injury and Organ Transplantation. Curr Pharm Biotechnol:19(15):1189-1195 doi: 10.2174/1389201020666190102150610

Kluever AK, Deindl E. (2018) Extracellular Nucleic Acids in Health and Disease. Curr Pharm Biotechnol:19(15):1180-1181 doi: 10.2174/138920101915190125142421

Vedantham S, Kluever AK, Deindl E. (2018) Is there a Chance to Promote Arteriogenesis by DPP4 Inhibitors Even in Type 2 Diabetes? A Critical Review. Cells doi: 10.3390/cells7100181

Weckbach LT, Preissner KT, Deindl E. (2018) The Role of Midkine in Arteriogenesis Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation. Int J Mol Scidoi: 10.3390/ijms19092559

Lasch M, Nekolla K, Klemm AH, Buchheim JI, Pohl U, Dietzel S, Deindl E.(2018) Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning. Mol Cell Biochem doi: 10.1007/s11010-018-3430-9

Buchheim JI, Hoskyns S, Moser D, Han B, Deindl E, Hörl M, Biere K, Feuerecker M, Schelling G, Choukèr A. (2018) Oxidative burst and Dectin-1-triggered phagocytosis affected by norepinephrine and endocannabinoids: implications for fungal clearance under stress. Int Immunol:30(2):79-89

Lautz T, Lasch M, Borgolte J, Troidl K, Pagel JI, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E. (2018) Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3. EBioMedicine:27:237-246

Kirsch J, Schneider H, Pagel JI, Rehberg M, Singer M, Hellfritsch J, Chillo O, Schubert KM, Qiu J, Pogoda K, Kameritsch P, Uhl B, Pircher J, Deindl E, Müller S, Kirchner T, Pohl U, Conrad M, Beck H. Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1891-9. doi: 10.1161/ATVBAHA.116.307843. Epub 2016 Jul 7. PMID: 27386940

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz AR, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.Cell Rep. 2016 Aug 23;16(8):2197-207.doi: 10.1016/j.celrep.2016.07.040. Epub 2016 Aug 11. PMID: 27524614

Lasch M, Caballero-Martinez A, Troidl K, Schloegl I, Lautz T, Deindl E. Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation. Lab Invest. 2016 Aug;96(8):830-8. doi: 10.1038/labinvest.2016.62. Epub 2016 May 30. PMID: 27239731

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. 2016 Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.

Trenkwalder T, Deindl E, Bongiovanni D, Lee S, Schunkert H, Kupatt C, Hinkel R. Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway. Expert Opin Biol Ther. 2015; 15 Suppl 1:S175-85

Chandraratne S, von Bruehl ML, Pagel JI, Stark K, Kleinert E, Konrad I, Farschtschi S, Coletti R, Gärtner F, Chillo O, Legate KR, Lorenz M, Rutkowski S, Caballero-Martinez A, Starke R, Tirniceriu A, Pauleikhoff L, Fischer S, Assmann G, Mueller-Hoecker J, Ware J, Nieswandt B, Schaper W, Schulz C, Deindl E, Massberg S. Critical role of platelet glycoprotein ibα in arterial remodeling. Arterioscler Thromb Vasc Biol. 2015; 35(3):589-97

Faber JE, Chilian WM, Deindl E, van Royen N, Simons M. A Brief Etymology of the Collateral Circulation. Arterioscler Thromb Vasc Biol. 2014 Jul 10; pii: ATVBAHA.114.303929.

Deindl E. Mechanistic insights into the functional role of vascular endothelial growth factor and its signalling partner brain-derived neurotrophic factor in angiogenic tube formation. Acta Physiol (Oxf). 2014 Jun; 211(2):268-70

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun. 2014 Jun 9; 5:3970

Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Müller-Höcker J, Deindl E, Sperandio M, Walzog B. (2014) The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ß2 integrins (CD11/CD18). Blood 2014 Mar 20; 123(12):1887-96

Qin D, Trenkwalder T, Lee S, Chillo O, Deindl E, Kupatt C, Hinkel R. Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. PLoS One. 2013 Apr 16; 8(4):e61831

Li YY, Yuece B, Cao HM, Lin HX, Lv S, Chen JC, Ochs S, Sibaev A, Deindl E, Schaefer C, Storr M. Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest. 2013 Mar; 93(3):322-33

Deindl E, Schaper W. Editorial: avenue to arteriogenesis. Curr Vasc Pharmacol. 2013 Jan; 11(1):2-4

Pagel JI, Deindl E. Disease progression mediated by egr-1 associated signaling in response to oxidative stress. Int J Mol Sci. 2012 Oct 12; 13(10):13104-1

Fischer S, Grantzow T, Pagel JI, Tschernatsch M, Sperandio M, Preissner KT, Deindl E. Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines. Thromb Haemost. 2012 Oct; 108(4):730-41.

Weckbach LT, Groesser L, Borgolte J, Pagel JI, Pogoda F, Schymeinsky J, Müller-Höcker J, Shakibaei M, Muramatsu T, Deindl E, Walzog B. Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am J Physiol Heart Circ Physiol. 2012 Aug 15; 303(4):H429-38

Pagel JI, Ziegelhoeffer T, Heil M, Fischer S, Fernández B, Schaper W, Preissner KT, Deindl E. Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo. Thromb Haemost. 2012 Mar; 107(3):562-74

Pagel JI, Borgolte J, Hoefer I, Fernández B, Schaper W, Deindl E. Involvement of neuronal NO synthase in collateral artery growth. Indian J Biochem Biophys. 2011 Aug; 48(4):270-4.

Pagel JI, Deindl E. Early growth response 1--a transcription factor in the crossfire of signal transduction cascades. Indian J Biochem Biophys. 2011 Aug; 48(4):226-35. Review.

Reichel CA, Uhl B, Lerchenberger M, Puhr-Westerheide D, Rehberg M, Liebl J, Khandoga A, Schmalix W, Zahler S, Deindl E, Lorenzl S, Declerck PJ, Kanse S, Krombach F. Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor.
Circulation. 2011 Oct 25; 124(17):1848-59.

Dussmann P, Pagel JI, Vogel S, Magnusson T, Zimmermann R, Wagner E, Schaper W, Ogris M, Deindl E. Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing. BMC Dev Biol 2011 May 20; 11:28

Fischer S, Nishio M, Dadkhahi S, Gansler J, Saffarzadeh M, Shibamiyama A, Kral N, Baal N, Koyama T, Deindl E, Preissner KT. Expression and localisation of vascular ribonucleases in endothelial cells. Thromb Haemost 2011 February 1; 105(2):345-55.

Dimomeletis I, Deindl E, Zaruba M, Groebner M, Zahler S, Laslo SM, David R, Kostin S, Deutsch MA, Assmann G, Mueller-Hoecker J, Michaela Feuring-Buske M, Franz WM. Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice. Exp Hematol 2010 Nov; 38(11):1105-14.

Deindl E, Fischer S, Preissner KT. New directions in inflammation and immunity: the multi-functional role of the extracellular RNA/RNase system. Indian J Biochem Biophys 2009 December; 46(6):461-6.

Heusch P, Aker S, Boengler K, Deindl E, van de SA, Klein K, Rassaf T, Konietzka I, Sewell A, Menazza S, Canton M, Heusch G, Di LF, Schulz R. Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. Am J Physiol Heart Circ Physiol 2010 August; 299(2):H446-H453.

Kampmann A, Fernandez B, Deindl E, Kubin T, Pipp F, Eitenmuller I, Hoefer IE, Schaper W, Zimmermann R.
The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis. 1. Mol Cell Biochem 2009 Feb; 322(1-2):15-23.

Mueller-Hoecker J, Beitinger F, Fernandez B, Bahlmann O, Assmann G, Troidl C, Dimomeletis I, Kaab S,
Deindl E. Of rodents and humans: a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins. Int J Med Sci 2008; 5(3):152-8.

Zaruba MM, Huber BC, Brunner S, Deindl E, David R, Fischer R, Assmann G, Herbach N, Grundmann S,
Wanke R, Mueller-Hoecker J, Franz WM. Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival. Cardiovasc Res 2008 March 1; 77(4):722-31.

Deindl E. Arteriogenesis: a focus on signal transduction cascades and transcription factors. Thromb Haemost 2007 November; 98(5):940-3.